pipemidic acid
pipemidic acid
CAS: 51940-44-4
Molecular Formula: C14H17N5O3
pipemidic acid - Names and Identifiers
| Name | pipemidic acid |
| Synonyms | pipram 1489rb pipemid piperamicacid pipemidic acid PIPEMIDIC ACID LABOTEST-BB LT00772244 Pipemidic Acid Anhydrous pyrido(2,3-d)pyrimidine-6-carboxylicacid,5,8-dihydro-8-ethyl-5-oxo-2-(1-piper 8-ETHYL-5,8-DIHYDRO-5-OXO-2-[1-PIPERAZINYL]PYRIDO[2,3-D]-PYRIMIDINE-6-CARBOXYLIC ACID 8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid |
| CAS | 51940-44-4 |
| EINECS | 257-530-2 |
| InChI | InChI=1/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22) |
pipemidic acid - Physico-chemical Properties
| Molecular Formula | C14H17N5O3 |
| Molar Mass | 303.32 |
| Density | 1.1931 (rough estimate) |
| Melting Point | 251-255℃ |
| Boling Point | 717℃ |
| Flash Point | >110°(230°F) |
| Water Solubility | Soluble in 1N sodium hydroxide or in DMSO. Insoluble in water |
| Solubility | Soluble in glacial acetic acid, insoluble in methanol, acetone, DMF, extremely insoluble in water, ethanol, chloroform, insoluble in benzene, soluble in dilute alkali or acid solution. |
| Vapor Presure | 2.86E-12mmHg at 25°C |
| Appearance | Light yellow crystalline powder |
| pKa | 4.14±0.20(Predicted) |
| Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
| Sensitive | Light Sensitive |
| Refractive Index | 1.7000 (estimate) |
| MDL | MFCD00057291 |
| Physical and Chemical Properties | Light yellow crystalline powder. Melting point 251-255 °c (decomposition). Soluble in acetic acid, difficult to dissolve in methanol, acetone, DMF, very difficult to dissolve in water, ethanol, chloroform, insoluble in benzene, soluble in dilute alkali or acid solution. Odorless and bitter. |
| Use | Antibacterial Drugs, Pseudomonas aeruginosa, Escherichia coli, shigella and other Gram-negative bacilli have strong antibacterial effect, for the treatment of acute urinary tract infection and other diseases |
pipemidic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 2 |
| RTECS | UV1153800 |
| HS Code | 29335990 |
| Toxicity | LD50 in mice (mg/kg): 4000 orally; 1000 i.p., 50 i.v. (Ficicchia) |
pipemidic acid - Upstream Downstream Industry
pipemidic acid - Standard
Authoritative Data Verified Data
This product is 8-ethyl-5-oxo-5, 8-dihydro-2-(l-piperazinyl) pyrido [2,3-d pyrimidine-6-carboxylic acid trihydrate. The content of C14H17N503 shall not be less than 98.5% calculated as anhydrous.
Last Update：2024-01-02 23:10:35
pipemidic acid - Trait
Authoritative Data Verified Data
- This product is a yellowish to yellow crystalline powder; Odorless.
- This product is slightly soluble in methanol, very slightly soluble in water, insoluble in ethanol or ether; Soluble in glacial acetic acid or sodium hydroxide solution.
Last Update：2022-01-01 11:56:56
pipemidic acid - Introduction
This product is trihydrate, CAS: 51940-44-4 is anhydrous
Last Update：2022-10-16 17:25:48
pipemidic acid - Differential diagnosis
Authoritative Data Verified Data
- appropriate amounts of this product and pipemidic acid reference product were dissolved and diluted with mobile phase to prepare a solution containing about 0.1 mg per 1 ml, which was used as the test solution and the reference solution. The retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution according to the chromatographic conditions under the relevant substances.
- take this product, add 0.01mol/L hydrochloric acid solution to dissolve and dilute to prepare a solution containing about 3% per 1 ml, and measure it by UV-Vis spectrophotometry (General rule 0401), there is an absorption maximum at a wavelength of 275nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 189).
Last Update：2022-01-01 11:56:56
pipemidic acid - Exam
Authoritative Data Verified Data
clarity of alkaline solution
take 0.5g of this product, Add 10ml of sodium hydroxide solution to dissolve, the solution should be clarified (General rule 0902).
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and quantitatively dilute to make a solution containing about 0.3mg per lml as a test solution; Take an appropriate amount for precision measurement, quantitative dilution with mobile phase to prepare a solution containing 0.6ug per lml as a control solution; Precise measurement of appropriate amount of control solution, quantitative dilution with mobile phase to prepare a solution containing 0.06ug per lml, as a sensitivity solution. Silica gel was bonded with decanesulfonic acid sodium solution (0512g of citric acid and 5.7g of decanesulfonic acid were dissolved in water and diluted to 1.7 ml).-Acetonitrile-methanol (60:20:20) as mobile phase; The detection wavelength was 275mn. The appropriate amount of pipemidic acid was taken, dissolved and diluted with mobile phase to prepare a solution containing about 0.3mg per 1 ml, which was placed in an open glass container and irradiated at 5cm for 3 hours (30W) under ultraviolet light. Or 6 hours (15W), the mixed solution of pipemidic acid and its degradation impurities (wherein the amount of impurities at the retention time of 0.8 and 1.2 relative to the main peak is not less than 0.2% ), and 20u1 is injected into the liquid chromatograph, the chromatogram showed that the retention time of pipemidic acid was about 18 minutes, and the separation degrees between the peaks of pipemidic acid and impurities at relative retention times 0.8 and 1.2 should be greater than 4.5 and 3.5, respectively. Take the sensitivity solution 20 u1, inject the human liquid chromatograph, record the chromatogram, the signal-to-noise ratio of the peak of the main component should be greater than 10; Then take 20ul of the test solution and the control solution, they were injected into the liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the peak area of a single impurity shall not be greater than the main peak area of the control solution (0.2% ) ; the sum of each impurity peak area shall not be greater than 5 times (1.0%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.25 times smaller than the main peak area of the control solution were ignored.
loss on drying
take this product, dry to constant weight at 105°C, weight loss should be 15.0% ~ 16.0% (General 0831).
ignition residue
take l.Og of this product, put it in a platinum crucible, and check it according to law (General rule 0841). The residue left shall not exceed 0.2%.
Heavy metals
take this product l. (G) place it in the Baijin crucible, slowly cauterize until it is completely carbonized, cool it, add 0.5~1.0 sulfuric acid to wet it, heat it at low temperature until the sulfuric acid is removed, then add 0.5 nitric acid, it is evaporated to dryness until the nitrogen oxide vapor is removed, then it is allowed to cool, and it is completely charred by ignition at 500-600 ° C. It shall be checked according to law (General Principles 0821 second law), and the content of heavy metals shall not exceed 20 parts per million.
Last Update：2022-01-01 11:56:57
pipemidic acid - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid dissolved in 20ml, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a clear blue color of the solution, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 30.33mg of C14H17N503.
Last Update：2022-01-01 11:56:57
pipemidic acid - Category
Authoritative Data Verified Data
quinolones.
Last Update：2022-01-01 11:56:57
pipemidic acid - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:56:58
pipemidic acid - Pipemidic acid tablets
Authoritative Data Verified Data
This product contains pipemidic acid (C14H17N503 • 3H20) should be labeled the amount of 95.0% to 105.0%.
trait
This product is a light yellow tablet or film-coated tablet, which shows a light yellow color after removing the coating.
identification
- take an appropriate amount of fine powder of this product, add mobile phase to dissolve and dilute to prepare about 0.1 mg of the solution was filtered, and the filtrate was taken as a test solution, and the same results were shown according to the identification (1) Test under the item of pipemidic acid.
- take an appropriate amount of fine powder of this product and add 0. The solution containing about 3UG of pipemidic acid per 1 ml was prepared by dissolving and diluting the 1 mol/L hydrochloric acid solution, filtered, and the filtrate was taken off, and the same result was shown according to the identification (2) test under the item of pipemidic acid.
examination
- relevant substances: take an appropriate amount of fine powder of this product, dissolve and quantitatively dilute it with mobile phase according to the labeled amount to make a solution containing about 0.3mg per 1 ml, filter it, and take the continued filtrate as the test solution; according to the method of determination of pipemidic acid, should comply with the provisions.
- dissolution of this product, according to the dissolution and release determination method (General 0931 first method), to O.Olmol/L hydrochloric acid solution 900ml as the dissolution medium, the rotation speed is 75 rpm, the operation is carried out according to law, after 30 minutes, take the appropriate amount of solution, filter, precision take the appropriate amount of filtrate, with O.Olmol/L hydrochloric acid solution was quantitatively diluted to make a solution containing about C14H17N503 • 3H203ug per 1 ml, and the absorbance was measured at the wavelength of 275nm according to ultraviolet-visible spectrophotometry (General rule 0401); in addition, the appropriate amount of pipemidic acid was weighed accurately, and O was added. Olmol/L hydrochloric acid solution was dissolved and quantitatively diluted to prepare a solution containing about C14H17N503 · 3H203ug per 1 ml, which was measured by the same method, and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (equivalent to C14H17N503 • 3H20 0.2g), put it in a 500ml measuring flask, add 0. The appropriate amount of Olmol/L hydrochloric acid solution was dissolved and diluted to the scale by ultrasound. The solution was shaken and filtered, and 2ml of the continuous filtrate was accurately measured, and then placed in a 250ml measuring flask. Olmol/L hydrochloric acid solution was diluted to the scale, then shaken, and the absorbance was measured at the wavelength of 275nm by UV-Vis spectrophotometry (General rule 0401), plus O.Olmol/L hydrochloric acid solution was dissolved and quantitatively diluted to prepare a solution containing about C14H17N503 • 3H203ug per 1 ml, which was determined by the same method. The content of C14H17N503. 3H20 in the test article was calculated.
category
with pipemidic acid.
specification
Based on C14H17N503 • 3H20 (1)0.25g(2)0.5g
storage
sealed storage.
Last Update：2022-01-01 11:56:59
pipemidic acid - Pipemidic acid capsules
Authoritative Data Verified Data
This product contains pipemidic acid (C14H17N503 • 3H20) should be labeled the amount of 95.0% to 105.0%.
identification
(1) take an appropriate amount of the contents of this product, add the mobile phase to dissolve and dilute to make about 0.1 mg of the solution was filtered, and the filtrate was taken as a test solution, and the same results were shown according to the identification (1) Test under the item of pipemidic acid.
(2) take an appropriate amount of the contents of this product, add 0.Olmol/L hydrochloric acid solution was dissolved and diluted to prepare a solution containing about 3% of pipemidic acid per 1 ml, filtered, and the filtrate was taken off, according to the identification (2) test under pipemidic acid, the same results are shown.
examination
- relevant substances: take an appropriate amount of the contents of this product, dissolve and quantitatively dilute it according to the labeled amount and the mobile phase to make a solution containing about 0.3mg per 1 ml, filter it, and take the continued filtrate as the test solution; according to the method of determination of pipemidic acid, should comply with the provisions.
- dissolution of this product, according to the dissolution and release determination method (General 0931 first method), to O.Olmol/L hydrochloric acid solution 900ml as the dissolution medium, the speed is 75 revolutions per minute, according to the operation, after 30 minutes, take the appropriate amount of solution, filtration, precise amount of filtrate, with 0.Olmol/L hydrochloric acid solution was quantitatively diluted to make a solution containing about C14H17N503 • 3H203ug per 1 ml, and the absorbance was measured at the wavelength of 275nm according to ultraviolet-visible spectrophotometry (General rule 0401); in addition, the appropriate amount of pipemidic acid was weighed accurately, and O was added. Olmol/L hydrochloric acid solution was dissolved and quantitatively diluted to prepare a solution containing about C14H17N503 · 3H203ug per 1 ml, which was measured by the same method, and the dissolution amount of each particle was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents under the item of difference in loading amount, mix them evenly, weigh an appropriate amount (approximately equivalent to 0.2g of C14H17N503 • 3H20) precisely, and place it in a 500ml measuring flask, add an appropriate amount of 0.01mol/L hydrochloric acid solution to dissolve pipemidic acid and use O. Dilute Olmol/L hydrochloric acid solution to the scale, shake well, filter, take 2ml of continuous filtrate accurately, put it in a 250ml measuring flask, use 0.Olmol/L hydrochloric acid solution was diluted to the scale, then shaken, and the absorbance was measured at the wavelength of 275nm by UV-Vis spectrophotometry (General rule 0401), A solution containing about C14H17N503 • 3H203ug per 1 ml was prepared by dissolving and quantitatively diluting with a 0.01mol/L hydrochloric acid solution, and measured by the same method to calculate the content of C14H17N503 • 3H20 in the test product.
category
with pipemidic acid.
specification
0.25g (C14H17N503 • 3H20)
storage
sealed storage.
Last Update：2022-01-01 11:56:59
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